Mechanism of antifoaming action of simethicone
| Autor: | Ljerka Brečević, Ingrid Bošan-Kilibarda, Franjo Strajnar |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
antidotes
poisoning surface-active agents surface tension foam density foam stability Chromatography Polydimethylsiloxane Chemistry Cationic polymerization Simethicone Antifoaming Agents Foaming agent Toxicology Surface tension chemistry.chemical_compound Defoamer Models Chemical Chemical engineering Pulmonary surfactant medicine Hydrophobic silica medicine.drug |
| Zdroj: | Journal of Applied Toxicology. 14:207-211 |
| ISSN: | 1099-1263 0260-437X |
| DOI: | 10.1002/jat.2550140311 |
| Popis: | The mechanism of the foam-inhibiting action of simethicone, mainly used against flatulence, has been studied. Its effect on foaming systems containing synthetic gastric juice and a surface-active substance (anionic surfactant, cationic surfactant, soap solution) was quantitated by measuring the surface tension, foam stability and initial foam density. The effect of simethicone on each of the examined systems was the result of the combination of two actions: the drainage of liquid from foam films and the rupture of relatively thick liquid films. The mechanism of these actions may be described as the liquid drainage followed by bridging of the liquid film by polydimethylsiloxane droplets, helped by hydrophobic silica particles also present in the antifoaming agent, leading to the rupture of the film surface and air escape. |
| Databáze: | OpenAIRE |
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