Effects of subthalamic lesions on peripheral and central arousal thresholds in cats
| Autor: | R.J. Atkins, D.F. Lindsley, R.J. Barton |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Time Factors
media_common.quotation_subject Stimulation Sensory system Electroencephalography Arousal Lesion Diencephalon Developmental Neuroscience Mesencephalon medicine Animals Attention media_common Cerebral Cortex Midbrain reticular formation Behavior Animal medicine.diagnostic_test Reticular Formation Sciatic Nerve Electric Stimulation Neurology Cats medicine.symptom Psychology Neuroscience Vigilance (psychology) |
| Zdroj: | Experimental Neurology. 26:109-119 |
| ISSN: | 0014-4886 |
| DOI: | 10.1016/0014-4886(70)90092-0 |
| Popis: | Bilateral lesions of the subthalamic region of the diencephalon cause animals to become less responsive and even inattentive to sensory stimuli. To understand more about subthalamic involvement in attention and vigilance cats were implanted with electrodes in order to compare peripheral (sciatic nerve stimulation) and central (midbrain reticular formation stimulation) EEG and behavioral arousal thresholds. After making bilateral subthalamic lesions five of the six animals showed increased sciatic EEG and behavioral arousal thresholds. This increase in peripheral-arousal thresholds was not simply a reflection of increased central-arousal thresholds, as four of these five had reticular-formation EEG and behavioral arousal thresholds which were either less than or the same as before the lesions were made. The latency for EEG arousal was two to four times longer than before the lesion in some threshold trials. Durations of EEG and behavioral arousal were observed to be shorter than before lesions, which was consistent with the animals' lack of sustained attention to sensory stimuli. There also appeared to be more slow-wave EEG activity following subthalamic lesions, which was perhaps related to the animals' waxing and waning state of vigilance with increased periods of inattention and drowsiness. Gross behavioral observation indicated that the animals were hypophagic, hypokinetic, and hyporesponsive. We suggest that subthalamic involvement in problems of attention and vigilance may be related to interruption of interconnections of limbic and and neocortical areas with subcortical regions, interconnections which are important in initiating and sustaining attention to sensory stimuli. |
| Databáze: | OpenAIRE |
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