Association of IL-6 -174GC and -572GC Polymorphisms with Susceptibility to Cervical Cancer and Ovarian Cancer
| Autor: | Mojgan Karimi-Zarchi, Fatemeh Asadian, Seyed Amir Shaker, Ahmad Hashemzehi, Hossein Golestanpour, Sepideh Setayesh, Hossein Neamatzadeh, Masoud Zare-Shehneh, Seyedeh Fatemeh Parsaeian |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Genotype Uterine Cervical Neoplasms Iran Gastroenterology Pathogenesis Polymorphism (computer science) Internal medicine Medicine Humans Genetic Predisposition to Disease Allele Interleukin 6 Alleles Cervical cancer Ovarian Neoplasms Polymorphism Genetic biology business.industry Interleukin-6 General Medicine medicine.disease Case-Control Studies biology.protein Female Restriction fragment length polymorphism business Ovarian cancer |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 22(9) |
| ISSN: | 2476-762X |
| Popis: | Background During the past decades, the expansion of molecular development has had a key role in understanding the basis of gynecological cancer. Interleukin-6 (IL-6) is known to be involved in the pathogenesis of different cancers. Here, we evaluated the association of IL-6 -174G>C and -572 G>C polymorphisms with susceptibility to cervical and ovarian cancers in an Iranian population. Methods A total of 131 cases with ovarian cancer, 124 cases with cervical cancer and 140 healthy subjects were enrolled to the study. DNA was extracted from peripheral blood cells of subjects to genotype the IL-6 -174G>C and -572 G>C polymorphisms by amplification refractory mutation system (RFLP) polymerase chain reaction (PCR). Results There was a significant association of IL-6 -174G>C CC genotype (OR= 3.231, 95% CI: 1.130-9.239, p=0.029) and C allele (OR = 1.915; 95%CI: 1.266-2.896, p=0.002) with an increased risk of ovarian cancer. Moreover, the IL-6 -174G>C CC genotype (OR= 3.162, 95% CI: 1.094-9.141, p=0.034) and C allele (OR = 1.724; 95%CI: 1.129-2.633, p=0.012) was associated with increased risk of cervical cancer. Conclusions This study showed that the IL-6 -174G>C polymorphism was associated with ovarian cancer and cervical cancer risk. However, IL-6 -572 G>C polymorphism was not associated. |
| Databáze: | OpenAIRE |
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