Substitution with testosterone as aromatizable substrate for induction of follicular maturation, estradiol production and ovulation in a patient with 17 alpha-hydroxylase deficiency
| Autor: | Ludwig Wildt, Peter Licht, B. Munzer, J. Neuwinger, T Sir-Petermann, E. Siebzehnrübl |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Ovulation endocrine system medicine.medical_specialty Time Factors medicine.drug_class Endocrinology Diabetes and Metabolism media_common.quotation_subject Stimulation Steroid biosynthesis Sensitivity and Specificity Endocrinology Hypergonadotropic hypogonadism Ovarian Follicle Internal medicine Internal Medicine medicine Humans Testosterone Progesterone media_common Adrenal Hyperplasia Congenital Estradiol Chemistry General Medicine medicine.disease Androgen Estrogen CYP17A1 Female Corticosterone hormones hormone substitutes and hormone antagonists |
| Zdroj: | Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 104(5) |
| ISSN: | 0947-7349 |
| Popis: | 17 alpha-Hydroxylase Deficiency (17 alpha-OHDS) is a rare defect of steroid biosynthesis, characterized by the inability to synthesize cortisol, androgens or estrogens, by the complete absence of follicular maturation, hypergonadotropic hypogonadism, primary amenorrhea and hypertension. Since the ovaries of such patients contain numerous primordial follicles, we hypothesized that the absence of spontaneous follicular maturation could be due to a lack of aromatizable substrate. To provide this substrate, testosterone was administered either by intra-ovarian injection or by vaginal administration. Ovarian stimulation was performed with human urinary gonadotropins. Follicular maturation and ovulation could be induced by this treatment, as determined from ultrasonography, the analysis of LH, estradiol and progesterone serum levels and the aspiration of oocytes from the mature follicles. Fertilization of these oocytes in vitro, however, did not succeed. We conclude that follicular maturation can be induced in 17 alpha-OHDS by gonadotropins when testosterone is provided as an aromatizable substrate and that estrogens are a necessary component of follicular maturation. |
| Databáze: | OpenAIRE |
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