Dual-responsive nanogels based on oligo(ethylene glycol) methacrylates and acidic co-monomers
| Autor: | Micaela A. Macchione, Ana Cristina Racca, M. Florencia Sacarelli, Graciela M. Panzetta-Dutari, Miriam Cristina Strumia, Catalina Biglione |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Dispersion polymerization
Ether 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Methacrylate 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Monomer chemistry Zeta potential Itaconic acid 0210 nano-technology Ethylene glycol Acrylic acid Nuclear chemistry |
| Zdroj: | Soft matter. 15(47) |
| ISSN: | 1744-6848 |
| Popis: | Ethylene glycol-based nanogels (NGs) have demonstrated their potential for the development of next-generation formulations for biomedical applications due to their interesting properties. In this work, monodispersed NGs based on oligo(ethylene glycol) methacrylates (OEG) were synthesized through free radical precipitation/dispersion polymerization assisted by ultrasonication. Di(ethylene glycol)methyl ether methacrylate (DEGMA) and oligo(ethylene glycol) methacrylate (OEGMA; Mn 475 g mol−1) were used as the main monomers, acrylic acid (AA) or itaconic acid (IA) as co-monomers (OEG-co-AA and OEG-co-IA, respectively) and tetraethylene glycol dimethacrylate (TEGDMA) as crosslinker. The physicochemical properties of OEG-co-AA and OEG-co-IA NGs were studied including hydrodynamic diameter, poly-dispersity index, zeta potential and pH/temperature responsiveness. Samples with 4 mol% of both AA and IA showed nanometric sizes. Regarding their thermo-responsiveness, unexpected differences between NGs with AA or with IA were observed. Besides, NGs did not impair the cell viability of a breast tumour cell line even when high concentrations were added to the culture medium. The properties of the synthetized NGs showed that either NGs with 4% AA or with 4% IA are outstanding candidates for biomedical applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|