Cellular damage in bacterial meningitis: An interplay of bacterial and host driven toxicity
| Autor: | Joerg R. Weber, Elaine Tuomanen |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Programmed cell death
Bacterial Toxins Immunology Cell Biology Neuroprotection Bacterial cell structure Meningitis Bacterial Microbiology Leukocytes medicine Animals Humans Immunology and Allergy Inflammation Innate immune system Bacteria Microglia Bacterial Infections Oxidative Stress medicine.anatomical_structure Neurology Blood-Brain Barrier Infectious disease (medical specialty) Toxicity Neurology (clinical) |
| Zdroj: | Journal of Neuroimmunology. 184:45-52 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2006.11.016 |
| Popis: | Bacterial meningitis is still an important infectious disease causing death and disability. Invasive bacterial infections of the CNS generate some of the most powerful inflammatory responses known in medicine. Although the components of bacterial cell surfaces are now chemically defined in exquisite detail and the interaction with several receptor pathways has been discovered, it is only very recently that studies combining these advanced biochemical and cell biological tools have been done. Additional to the immunological response direct bacterial toxicity has been identified as an important contributor to neuronal damage. A detailed understanding of the complex interaction of bacterial toxicity and host response may generate opportunities for innovative and specific neuroprotective therapies. |
| Databáze: | OpenAIRE |
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