Molecular epidemiology of HIV type 1 in northern Brazil: identification of subtypes C and D and the introduction of CRF02_AG in the Amazon region of Brazil
| Autor: | V. N. Azevedo, Ricardo Ishak, Luiz Fernando Almeida Machado, Márcio Ronaldo Chagas Moreira, Luciana M. Fernandes, Maria I.M. Souza, Marluísa de Oliveira Guimarães Ishak, Lia Lobato Batista de Souza, Antonio Carlos Rosário Vallinoto, José Alexandre Rodrigues de Lemos |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Adolescent Genotype Immunology Population Human immunodeficiency virus (HIV) Sequence Homology HIV Infections medicine.disease_cause Genetic analysis Virus Central laboratory Young Adult HIV Protease Virology medicine Cluster Analysis Humans education Phylogeny Aged education.field_of_study Molecular Epidemiology Molecular epidemiology Amazon rainforest business.industry env Gene Products Human Immunodeficiency Virus virus diseases Sequence Analysis DNA Middle Aged Infectious Diseases HIV-1 Female business Brazil |
| Zdroj: | AIDS research and human retroviruses. 25(10) |
| ISSN: | 1931-8405 |
| Popis: | The molecular epidemiology of HIV-1 strains circulating in Belem-PA and Macapa-AP, in the Northern region of Brazil, is described using sequences of the C2V3 segment of the env and the pro gene of HIV-1 from patients of the Reference Unit for Special Infectious and Parasitary Diseases (URE-DIPE) in Belem-PA and the Central Laboratory (LACEN) in Macapa-AP. Subtype B was the most frequently found in relation to pro (88.3%) in Belem and in Macapa (97.1%) and env (88.3% in Belem and 100% in Macapa). Subtype F was also described in Belem (9.3% pro and 8.3% env) and Macapa (2.8% pro). Subtype D was described for the first time in the Northern region of the country as well as the recent entry of CRF02_AG. Furthermore, several possible recombinant forms among the various subtypes were found in both cities. The results support the hypothesis that HIV-1 infection is associated with the epidemic of the virus in the Southeast region of the country and that the city of Belem is the most important route for HIV-1 entry in the Northern region of Brazil. |
| Databáze: | OpenAIRE |
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