High preoperative plasma fibrinogen and serum albumin score is associated with poor survival in operable esophageal squamous cell carcinoma
| Autor: | Fen-Hua Liang, Zheng-Xia Mo, Yu Wang, Ling Li, Shu-Yan Sun, Cai-Hong Sun, Ling-Xin Meng, Ping-Ping Chen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Esophageal Neoplasms Serum albumin Fibrinogen Gastroenterology Severity of Illness Index Disease-Free Survival 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine medicine Biomarkers Tumor Humans Survival analysis Serum Albumin Aged Proportional Hazards Models Retrospective Studies Aged 80 and over biology Proportional hazards model business.industry Hazard ratio Albumin General Medicine Middle Aged Prognosis Confidence interval Esophagectomy Quartile 030220 oncology & carcinogenesis Preoperative Period biology.protein Regression Analysis 030211 gastroenterology & hepatology Female Esophageal Squamous Cell Carcinoma business medicine.drug |
| Zdroj: | Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. 32(1) |
| ISSN: | 1442-2050 |
| Popis: | This study was performed to investigate the prognostic significance of a cumulative score based on the preoperative plasma fibrinogen and serum albumin (FA score) in operable esophageal squamous cell carcinoma (ESCC). Clinicopathologic characteristics, preoperative fibrinogen, and albumin concentrations were retrospectively reviewed in patients who underwent transthoracic esophagectomy. The optimal cutoff value was defined as 4.0 g/L for fibrinogen according to previous studies and as 41.0 g/L for albumin for the lower quartile. Subjects with elevated fibrinogen and decreased albumin levels were allocated a score of 2, those with only one of these two abnormalities were assigned a score of 1, and those with neither of the abnormalities were allocated a score of 0. The preoperative FA score was significantly associated with tumor length, depth of invasion, lymph node involvement, tumor-node-metastasis (TNM) stage, and the modified Glasgow Prognostic Score (mGPS). No significant differences in age, gender, tumor location, degree of differentiation, smoking or alcohol consumption were found between groups. Univariate survival analysis revealed that high preoperative FA score (1/2) was significantly associated with unfavorable disease-free survival (DFS) [hazard ratio (HR), 1.675; 95% confidence interval (CI), 1.278-2.195; P < 0.001] and overall survival (OS) (HR, 1.685; 95% CI, 1.268-2.239; P < 0.001). Furthermore, it remained an independent prognostic indicator for both DFS (HR, 1.394; 95% CI, 1.035-1.879; P = 0.029) and OS (HR, 1.369; 95% CI, 1.010-1.878; P = 0.048) in multivariable Cox regression analysis. A high preoperative FA score could significantly predict impaired long-term survival for ESCC patients who underwent transthoracic esophagectomy. |
| Databáze: | OpenAIRE |
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