Particle size effect of curcumin nanosuspensions on cytotoxicity, cellular internalization, in vivo pharmacokinetics and biodistribution
| Autor: | Xiao Qing Miao, Albert H. L. Chow, Yong-Hong Liao, Chao Bi, Ying Zheng, Ru Yan, Sing Fung Chow, Wenjin Wu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Biodistribution Curcumin Materials science Cell Survival media_common.quotation_subject Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Antineoplastic Agents Bioengineering 02 engineering and technology Pharmacology 030226 pharmacology & pharmacy Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In vivo Cell Line Tumor Neoplasms Animals Humans Tissue Distribution General Materials Science Particle Size Cytotoxicity Internalization media_common 021001 nanoscience & nanotechnology In vitro Bioavailability Mice Inbred C57BL chemistry Nanoparticles Molecular Medicine Particle size 0210 nano-technology |
| Zdroj: | Nanomedicine: Nanotechnology, Biology and Medicine. 13:943-953 |
| ISSN: | 1549-9634 |
| DOI: | 10.1016/j.nano.2016.11.004 |
| Popis: | This study aimed to investigate the particle size effect on bioactivity, cellular internalization and bioavailability of curcumin (CUR) nanosuspension (CUR-NS). CUR-NSs of different particle sizes were prepared by two different anti-solvent precipitation methods. CUR-NS with the smallest size showed similar in vitro anticancer activity and bioavailability to the CUR solution, whereas nanosuspensions of larger particle sizes displayed higher in vitro cellular internalization and cytotoxicity, as well as higher in vivo AUC and slower clearance rate after i.v. administration in rats. CUR solution and different sized CUR-NSs reached the highest concentrations in the lung, followed by liver and spleen while the lowest concentration was observed in the brain after i.v. administration in mice. Specifically, CUR-NS of 70nm accumulated more in the brain, whereas CUR-NS of 200nm accrued more in liver and spleen. CUR-NS of 20nm displayed no significant biodistribution difference compared with CUR solution in all tissues. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect