Proliferative effects of chishao on injured peripheral neurons
| Autor: | Wu Hsien Kuo, Hsi Hsien Hsu, Chung Yen Lu, Chih Yang Huang, Wen Kuei Fang, Chien Chung Lin, Mu Hsin Chang, Yueh-Sheng Chen, Yi Jiun Weng, Chang Hai Tsai, Fuu Jen Tsai |
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| Rok vydání: | 2010 |
| Předmět: |
MAPK/ERK pathway
medicine.medical_specialty Biology Paeonia Plant Roots Rats Sprague-Dawley Internal medicine Plasminogen Activator Inhibitor 1 medicine Animals Fibroblast Extracellular Signal-Regulated MAP Kinases Cell Proliferation Neurons Dose-Response Relationship Drug Kinase Regeneration (biology) JNK Mitogen-Activated Protein Kinases General Medicine Sciatic Nerve Urokinase-Type Plasminogen Activator Nerve Regeneration Rats medicine.anatomical_structure Endocrinology Complementary and alternative medicine Fibroblast Growth Factor 2 Neuron Sciatic nerve Signal transduction Plasminogen activator Drugs Chinese Herbal Phytotherapy Signal Transduction |
| Zdroj: | The American journal of Chinese medicine. 38(4) |
| ISSN: | 1793-6853 |
| Popis: | The aim of the study was to evaluate the proliferative effects of chishao on neuron regeneration. A silicone rubber nerve guide across a 15-mm gap was filled with different concentrations of chishao (0–125 mg/ml) in the dissected sciatic nerve of the right leg in SD rats. The left legs were used as control. After eight weeks, the regenerated nerves showed dose-dependently activated fibroblast growth factor-2 (FGF-2) signaling with increased urokinase plasminogen activator (uPA), decreased plasminogen activator inhibitor-1 (PAI-1) and enhanced proliferative proteins, extracellular signal regulated kinase (ERK)- and c-Jun N-terminal kinase (JNK)-signalings. The results imply that applying an appropriate dose of chishao would be a potential approach for enhancing neuron regeneration. |
| Databáze: | OpenAIRE |
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