Azathioprine induced fever, chills, rash, and hepatotoxicity in rheumatoid arthritis
| Autor: | Marijn W. M. Kruijsen, L. B. A. Van De Putte, A. M. T. Boerbooms, M. E. C. Jeurissen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Fever Nausea Immunology Azathioprine Gastroenterology General Biochemistry Genetics and Molecular Biology Arthritis Rheumatoid Drug Hypersensitivity Rheumatology Cholestasis Internal medicine medicine Immunology and Allergy Humans Aged business.industry Liver Diseases Middle Aged medicine.disease Rash Discontinuation Surgery Liver Rheumatoid arthritis Chills Female Liver function Drug Eruptions medicine.symptom Chemical and Drug Induced Liver Injury business medicine.drug Research Article |
| Popis: | Within one year three of 25 patients with rheumatoid arthritis treated with azathioprine 100 mg daily developed the following adverse reactions less than two weeks after starting treatment: patient one showed fever with chills, rash, and severe liver function abnormalities suggestive of cholestasis; the second patient had fever, nausea, diarrhoea, and moderately raised liver enzymes; the third patient showed very high fever and severe chills. In two patients the drug was rechallenged, with more rapidly arising and more severe symptoms. In one case raised liver enzymes persisted until seven months after discontinuation of azathioprine. Hypersensitivity reactions and hepatotoxicity of azathioprine are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|