Implication of glucocorticoid in anti-inflammatory effects of Ro5-4864 in mouse pleurisy induced by carrageenan
| Autor: | Marcelo Barreto Spillere da Silva, Tânia Silvia Fröde, Roseli C. Farges |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Leukocyte migration Adenosine Deaminase Neutrophils medicine.drug_class Anti-Inflammatory Agents Pharmacology Carrageenan Nitric Oxide Peripheral blood mononuclear cell General Biochemistry Genetics and Molecular Biology Anti-inflammatory Nitric oxide Mice chemistry.chemical_compound Adrenergic Agents Cell Movement medicine Animals General Pharmacology Toxicology and Pharmaceutics Glucocorticoids Pleurisy Peroxidase Benzodiazepinones biology General Medicine medicine.disease Aminoglutethimide Chemotaxis Leukocyte chemistry Myeloperoxidase Immunology biology.protein Female Glucocorticoid medicine.drug |
| Zdroj: | Life Sciences. 78:1814-1822 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/j.lfs.2005.08.021 |
| Popis: | Mouse pleurisy induced by carrageenan is used to determine the mechanism of anti-inflammatory action of 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2-H-1,4-benzodiazepin-2 (Ro5-4864). Pre-treatment with Ro5-4864 inhibits different inflammatory parameters, such as neutrophil influx, MPO activity and NO levels in the early phase (4 h), as well as mononuclear cells and ADA activity in the late phase (48 h) of pleurisy. dl-Aminoglutethimide, inhibitor of steroidal synthesis, reverted the effect of Ro5-4864 on these different inflammatory parameters. Our results suggest that anti-inflammatory action of Ro5-4864 may be partly due to its capacity to inhibit leukocyte migration, as well as leukocyte activation and formation of NO by a mechanism dependent on glucocorticoids. |
| Databáze: | OpenAIRE |
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