Decreased nitric oxide production after intravenous immunoglobulin treatment in patients with Kawasaki disease
| Autor: | Hsiu-Chin Liu, Yu-Tsun Wu, Chia-Jung Lee, Chih-Lu Wang, Kuender D. Yang, Li-Tung Huang |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Urinary system Taiwan Child Welfare Renal function Mucocutaneous Lymph Node Syndrome Kidney Nitric Oxide Immunoglobulin E Peripheral blood mononuclear cell Nitric oxide Excretion chemistry.chemical_compound hemic and lymphatic diseases Internal medicine medicine Humans RNA Messenger Child biology Reverse Transcriptase Polymerase Chain Reaction business.industry Immunoglobulins Intravenous medicine.disease Immunohistochemistry Pathophysiology Isoenzymes Treatment Outcome Endocrinology chemistry Pediatrics Perinatology and Child Health Immunology Leukocytes Mononuclear biology.protein Kawasaki disease Nitric Oxide Synthase business |
| Zdroj: | The Journal of Pediatrics. 141:560-565 |
| ISSN: | 0022-3476 |
| DOI: | 10.1067/mpd.2002.127505 |
| Popis: | Objective: To assess nitric oxide (NO) production and different displays of NO synthase (NOS) isoforms in patients with Kawasaki disease (KD) before and after intravenous immunoglobulin (IVIG) treatment. Study design: Blood and urine samples were collected from patients with KD before IVIG treatment and 3 days afterward. Age-matched febrile patients with various diseases served as control patients. Plasma NOx (NO3- + NO2-) levels were measured as NO production. Real-time reverse transcriptase–polymerase chain reaction and immunohistochemical staining were used to detect differential NOS isoform expression in mononuclear leukocytes (MNCs). Results: Patients with KD (n = 40) had higher levels of NOx than the non-KD febrile control patients. The elevated NOx levels in patients with KD were significantly associated with the occurrence of coronary artery dilation (>3 mm). These elevated NOx levels significantly decreased after IVIG treatment (157.8 ± 15.9 μmol/L vs 57.0 ± 4.27 μmol/L, P |
| Databáze: | OpenAIRE |
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