Studies on the mechanism of carbon monoxide toxicity
| Autor: | Karel B. Absolon, Charles Briggs, Mohammed Alijani, Tristan Orellano, Leo R. Goldbaum, Javier Vasquez, Elias Dergal |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Anemia
Hemolytic medicine.medical_specialty Blood transfusion medicine.medical_treatment Intraperitoneal injection Poison control Hypothermia Carbon Monoxide Poisoning chemistry.chemical_compound Dogs Animals Medicine Blood Transfusion Carbon Monoxide Dose-Response Relationship Drug Inhalation business.industry Carbon monoxide poisoning Respiration medicine.disease Surgery Carboxyhemoglobin chemistry Anesthesia Toxicity medicine.symptom business Injections Intraperitoneal |
| Zdroj: | Journal of Surgical Research. 20:485-487 |
| ISSN: | 0022-4804 |
| DOI: | 10.1016/0022-4804(76)90125-6 |
| Popis: | Inhalation of 13% CO in dogs for 5 min was lethal in minutes to hours, hypothermia having only a minimal effect on survival. Even though the blood levels after CO inhalation were similar to those induced by transfusion of COHb red cells (64%, respectively, 60% COHb), no toxicity was observed in the latter. Intraperitoneal injections of 100% CO in amounts of up to 150 ml/kg of body weight daily for 90 days to a cummulative dose of 90 liters produced similar COHb blood levels and was nontoxic. Chronic intraperitoneal injection of CO presents a new model to study chronic effects of CO. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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