Genetic diversity of HLA system in two populations from Chiapas, Mexico : Tuxtla Gutiérrez and rural Chiapas
| Autor: | Vicencio Juárez-Barreto, Komathi Sree Ponnandai-Shanmugavel, Esteban Arrieta-Bolaños, Rodrigo Barquera, Tannya Verónica Vázquez-Castillo, Raquel García-Álvarez, Diana Iraíz Hernández-Zaragoza, María Araceli Arrazola-García, Virginia Martínez-Bezies, Alicia Bravo-Acevedo, Ariadna Berenice Escutia-González, Carolina Bekker-Méndez, Francisco Juárez-Nicolás, Alexander Immel, Joaquín Zúñiga, Edmond J. Yunis, Norma Salgado-Galicia, María del Rosario Vega-Martínez, Raúl Solís-Martínez, Andrea Ortega-Yáñez, Julio Granados, Julio César Martínez-Álvarez, Bárbara Novelo-Garza, Stephen Clayton, Gamaliel Benítez-Arvizu |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Rural Population
Genetic diversity Geography Immunology Medizin Population genetics Genetic Variation General Medicine Human leukocyte antigen Immunogenetics Linkage Disequilibrium Genetics Population Gene Frequency Haplotypes Evolutionary biology HLA Antigens Ethnicity Immunology and Allergy Humans Cities Mexico Alleles |
| Popis: | We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 173 Mexicans from the state of Chiapas living in the city of Tuxtla Gutiérrez (N = 52) and rural communities (N = 121), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in Chiapas include 12 Native American and one European haplotype. Admixture estimates revealed that the main genetic components in Chiapas are Native American (71.61 ± 0.58% by ML; 53.16% of Native American haplotypes) and European (26.39 ± 5.05% by ML; 25.86% of European haplotypes), and a less prominent African genetic component (2.00 ± 5.20% by ML; 9.77% of African haplotypes). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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