| Autor: |
Xuefei Yu, Catherine Arden, Rolando Berlinguer-Palmini, Chun Chen, Carla Bradshaw, Anna LM Smith, Julia Whitehall, Michael White, Scott Anderson, Nicole Kattner, James Shaw, Doug Turnbull, Laura C Greaves, Mark Walker |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Molecular metabolism. 60 |
| ISSN: |
2212-8778 |
| Popis: |
There is strong evidence that mitochondrial DNA mutations and mitochondrial dysfunction play a role in diabetes pathogenesis. The homozygous knock-in mtDNA mutator mouse is a model of premature aging due to the accumulation of mitochondrial DNA mutations. We used this mouse model to investigate the relationship between mitochondrial subunit expression and pancreatic islet cell composition.Quadruple immunofluorescence was used to quantify mitochondrial subunit expression (complex I and IV) and cell composition in pancreatic islets from mitochondrial DNA mutator mice (PolgAMitochondrial complex I subunit expression was decreased in islets from 12 week PolgAComplex I deficiency promotes α-cell proliferation and alters islet cell composition. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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