Effect of Nifedipine on Oesophageal Motility and Gastric Emptying
| Autor: | S Holt, R C Heading, J N Blackwell |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Nifedipine Pyridines Achalasia Gastroenterology Oesophageal motility Placebos Random Allocation Internal medicine otorhinolaryngologic diseases medicine Humans In patient Peristalsis Clinical Trials as Topic Gastric emptying business.industry digestive oral and skin physiology Healthy subjects Parasympatholytics Muscle Smooth Middle Aged Diffuse oesophageal spasm medicine.disease Esophageal Achalasia Gastric Emptying Depression Chemical Female Esophagogastric Junction Gastrointestinal Motility business Muscle Contraction medicine.drug |
| Zdroj: | Digestion. 21:50-56 |
| ISSN: | 1421-9867 0012-2823 |
| DOI: | 10.1159/000198520 |
| Popis: | Manometric studies have been performed to determine the effect of nifedipine on lower oesophageal sphincter (LOS) pressure and distal oesophageal motility in healthy subjects, in patients with diffuse oesophageal spasm, and in a patient with achalasia. Significant reductions in LOS pressure and in the amplitude of peristaltic oesophageal contractions were observed. In the patients with diffuse oesophageal spasm the amplitude and frequency of non-peristaltic (spasm) contractions were also reduced. Nifedipine did not significantly influence gastric emptying rates of solid and liquid components of a test meal in normal subjects nor in patients who had undergone gastric surgery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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