Towards validating stent induced micro flow patterns in left main coronary artery bifurcations
| Autor: | Mark Webster, John A. Ormiston, Sina Masoud-Ansari, Susann Beier, Brett R. Cowan, Beau Pontre |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Scale (ratio) Quantitative Biology::Tissues and Organs medicine.medical_treatment Physics::Medical Physics 0206 medical engineering 02 engineering and technology Computational fluid dynamics 030218 nuclear medicine & medical imaging Physics::Fluid Dynamics 03 medical and health sciences 0302 clinical medicine medicine Newtonian fluid Humans Computer Simulation Image resolution business.industry Models Cardiovascular Stent Blood flow Mechanics 020601 biomedical engineering Coronary Vessels medicine.anatomical_structure Flow (mathematics) Hydrodynamics Stents business Blood Flow Velocity Artery |
| Zdroj: | EMBC |
| ISSN: | 2694-0604 |
| Popis: | We investigated if blood flow changes induced through the presence of a stent could be detected using in vitro dynamically scaled 4D Phase-Contrast Magnetic Resonance Imaging (PC-MRI). Using idealized and patient-specific left main coronary artery bifurcations, we 3D-printed the dynamically large scaled geometries and incorporated them into a flow circuit for non-invasive acquisition with a higher effective spatial resolution. We tested the effects of using non-Newtonian and Newtonian fluids for the experiment. We also numerically simulated the same geometries in true scale for comparison using computational fluid dynamics (CFD). We found that the experimental setup increased the effective spatial resolution enough to reveal stent induced blood flow changes close to the vessel wall. Non-Newtonian fluid replicated all of the flow field well with a strong agreement with the computed flow field (R2 > 0.9). Fine flow structures were not as prominent for the Newtonian compared to non-Newtonian fluid consideration. In the patient-specific geometry, arterial non-planarity increased the difficulty to capture the near wall slow velocity changes. Findings demonstrate the potential to dynamically scale in vitro 4D MRI flow acquisition for micro blood flow considerations. |
| Databáze: | OpenAIRE |
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