Efficacy of Proanthocyanidins from Pelargonium sidoides Root Extract in Reducing P. gingivalis Viability While Preserving Oral Commensal S. salivarius

Autor:	Andrea Cochis, Nijole Savickiene, Asmaa Sayed Abdelgeliel, Maija Dambrova, Ingrida Pacauskiene, Nomeda Baseviciene, Aiste Jekabsone, Lina Raudone, Lia Rimondini, Elina Makarova, Pranas Viškelis, Solveiga Grinberga, Osvalds Pugovics
Rok vydání:	2018
Předmět:	0301 basic medicine Antioxidant LC/MS/MS medicine.drug_class medicine.medical_treatment Antibiotics antioxidant activity Pelargonium sidoides lcsh:Technology 03 medical and health sciences medicine General Materials Science lcsh:Microscopy Porphyromonas gingivalis lcsh:QC120-168.85 Innate immune system lcsh:QH201-278.5 biology Traditional medicine lcsh:T Pelargonium sidoides root extract bacteriotoxicity biology.organism_classification 030104 developmental biology Streptococcus salivarius Proanthocyanidin lcsh:TA1-2040 lcsh:Descriptive and experimental mechanics lcsh:Electrical engineering. Electronics. Nuclear engineering lcsh:Engineering (General). Civil engineering (General) proanthocyanidins Antibacterial activity lcsh:TK1-9971
Zdroj:	Materials, MDPI, 2018, 11, p. 1-15 Materials Volume 11 Issue 9 Materials, Vol 11, Iss 9, p 1499 (2018)
ISSN:	1996-1944
DOI:	10.3390/ma11091499
Popis:	Bacterial resistance to antibiotics and the disruption of beneficial microbiota are key problems in contemporary medicine and make the search for new, more efficient infection treatment strategies among the most important tasks in medicine. Multicomponent plant-derived preparations with mild antibacterial activity created by many simultaneous mechanisms together with anti-inflammatory, innate immune and regenerative capacity-stimulating properties are good candidates for this therapy, and proanthocyanidins are among the most promising compounds of this sort. In this study, we have isolated proanthocyanidins from Pelargonium sidoides DC root extract and characterized and compared the composition, antioxidant properties and antibacterial activity of the proanthocyanidin fraction with those of the whole extract. The results revealed that proanthocyanidins had significantly stronger antioxidant capacity compared to the root extract and exhibited a unique antibacterial action profile that selectively targets Gram-negative keystone periodontal and peri-implant pathogenic strains, such as Porphyromonas gingivalis, while preserving the viability of beneficial oral commensal Streptococcus salivarius. The finding suggests that proanthocyanidins from Pelargonium sidoides root extract are good candidates for the prolonged and harmless treatment of infectious diseases.
Databáze:	OpenAIRE
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