Comparative antibody response in harbour and grey seals naturally infected by a morbillivirus
| Autor: | J. R. Geraci, Noel Duffy, Bert K. Rima, Pádraig J. Duignan |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Radioimmunoprecipitation Assay
Seals Earless animal diseases Immunology Hemagglutinin (influenza) Biology Antibodies Viral Virus Morbillivirus Antigen Neutralization Tests medicine Animals Distemper Virus Canine Distemper Virus Phocine chemistry.chemical_classification General Veterinary medicine.disease biology.organism_classification Virology Titer chemistry biology.protein Female Antibody Glycoprotein Morbillivirus Infections Encephalitis |
| Zdroj: | Veterinary Immunology and Immunopathology. 55:341-349 |
| ISSN: | 0165-2427 |
| Popis: | The antibody response of free-ranging harbour and grey seals, naturally infected by a morbillivirus, was assessed using a virus neutralizing test and a radio-immunoprecipitation assay. The prevalence of antibody was similar between species, however, grey seals had significantly higher virus neutralizing titers. Serum from clinically healthy grey seals precipitated the nucleocapsid (N) protein along with the hemagglutinin (H) and fusion (F) glycoproteins. By contrast, significantly fewer harbour seal sera precipitated the envelope glycoproteins and responses were weaker than those of grey seals. One harbour seal with acute morbillivirus pneumonia, and two with encephalitis precipitated only the N protein. Serum from four harbour seals with encephalitis weakly recognized the envelope glycoproteins. Thus, the antibody response of grey seals appears more competent than that of harbour seals with respect to morbillivirus antigens. We speculate that this difference between the species may be an important determinant of morbillivirus susceptibility. |
| Databáze: | OpenAIRE |
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