Cardiovascular Autonomic Response to Orthostatic Stress Under Hypoxia in Patients with Spinal Cord Injury
| Autor: | Shu-Chun Huang, Shih-Chieh Chang, Kuo-Cheng Liu, Jong-Shyan Wang, Alice M. K. Wong |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 030506 rehabilitation medicine.medical_specialty Physiology Blood Pressure Cardiovascular System 03 medical and health sciences 0302 clinical medicine Heart Rate Tilt-Table Test Internal medicine Supine Position medicine Humans Heart rate variability In patient Hypoxia Spinal cord injury Spinal Cord Injuries business.industry Public Health Environmental and Occupational Health Stroke Volume General Medicine Hypoxia (medical) Spinal cord medicine.disease Adaptation Physiological Autonomic cardiovascular function medicine.anatomical_structure Case-Control Studies Chronic Disease Orthostatic Intolerance Orthostatic stress Vascular resistance Cardiology Vascular Resistance medicine.symptom 0305 other medical science business 030217 neurology & neurosurgery |
| Zdroj: | High Altitude Medicine & Biology. 19:201-207 |
| ISSN: | 1557-8682 |
| DOI: | 10.1089/ham.2017.0154 |
| Popis: | Huang, Shu-Chun, Kuo-Cheng Liu, Alice M.K. Wong, Shih-Chieh Chang, and Jong-Shyan Wang. Cardiovascular autonomic response to orthostatic stress under hypoxia in patients with spinal cord injury. High Alt Med Biol. 19:201-207, 2018.Determining whether systemic hypoxia aggravates the severity of autonomic cardiovascular dysfunction in orthostatic stress among patients with spinal cord injuries (SCIs).Twenty-four male patients with chronic SCI whose neurological levels were above T6 were recruited. Twenty-five healthy men were enrolled in the control group. Five-minute supine rest (SR) and head-up tilt (HUT) at 60° were performed in normoxia and after 1 hour, 13.5% fraction of inspired OIn normoxia from SR to HUT, systolic and diastolic BPs declined, SV decreased, and heart rate increased, whereas CO and TPR showed a declining trend in the SCI group. Sympathetic activation and vagal withdrawal were also disclosed in the HRV analysis. In hypoxia, the change of these cardiovascular responses from SR to HUT exhibited no difference to normoxia in the SCI group. No significant difference in arterial desaturation was observed between the two groups (82.9% vs. 80.4%).Cardiovascular adaptation to orthostatic stress is not affected by subacute steady-state hypoxia in chronic SCI patients with neurological levels higher than T6. |
| Databáze: | OpenAIRE |
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