A focus on resveratrol and ocular problems, especially cataract: From chemistry to medical uses and clinical relevance
| Autor: | Seyed Mohammad Nabavi, Maria Daglia, R. Thiagarajan, Ramar Manikandan, William N. Setzer, Ganesh Goutham, Munusamy Arumugam, M. Beulaja, Seyed Fazel Nabavi, C. Arulvasu |
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| Přispěvatelé: | Goutham, Ganesh, Manikandan, Ramar, Arulvasu, Chinnasamy, Arumugam, Munusamy, Beulaja, Manikandan, Thiagarajan, Raman, Setzer William, N., Daglia, Maria, Nabavi Seyed, Fazel, Nabavi Seyed, Mohammad |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty genetic structures Glaucoma Resveratrol Phytochemical Bioinformatics Ocular disease Antioxidants Cataract 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cataracts Stilbenes medicine Animals Humans Clinical significance Pharmacology business.industry Animal Oxidative Stre General Medicine Diabetic retinopathy Macular degeneration medicine.disease eye diseases Surgery Low vision Clinical trial Oxidative Stress 030104 developmental biology chemistry 030220 oncology & carcinogenesis Stilbene sense organs Lipid Peroxidation Antioxidant business Human |
| Zdroj: | Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 86 |
| ISSN: | 1950-6007 |
| Popis: | Low vision and blindness are important health problems that affect millions of people throughout the world. The most common and important pathologies are diabetic retinopathy, age-related macular degeneration, glaucoma as well as cataracts. The latter consists of an opacification of the lens of the eye which impedes the passage of light and represents one of the most important causes of vision loss. Among the risk factors for cataract development, there are life-style factors such as the use of tobacco, abuse of alcohol and unhealthy diet. In light of this, dietary components that possess anti-oxidant activity, such as polyphenols for instance, can be considered good candidates for human studies in the prevention and or treatment of such diseases. Among dietary components, the antioxidant capacity of certain polyphenols is well known, and these could be good candidates. In this review we focus our attention on the current scientific literature regarding to the effects of resveratrol on cataracts and other ocular diseases, along with its potential mechanism/s of action. A large number of preclinical studies support the involvement of resveratrol in clinical trials for the prevention and treatment of eye diseases induced by oxidative stress and inflammation, such as age-related cataract. |
| Databáze: | OpenAIRE |
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