HCV-specific CD4+ T cells of patients with acute and chronic HCV infection display high expression of TIGIT and other co-inhibitory molecules
| Autor: | Silke Kummer, William W. Kwok, Thomas Jacobs, Julian Schulze zur Wiesch, Ansgar W. Lohse, Sven Peine, Matthias Marget, Tobias Boettler, Christin Ackermann, Thomas Kuntzen, Robin Woost, Maike Smits, Johanna M. Eberhard |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male 0301 basic medicine CD226 Programmed Cell Death 1 Receptor BTLA lcsh:Medicine Hepacivirus Immunological memory Article Young Adult 03 medical and health sciences 0302 clinical medicine TIGIT MHC class I Humans Medicine Receptors Immunologic Receptor lcsh:Science Hepatitis A Virus Cellular Receptor 2 Aged Multidisciplinary biology Hepatitis C virus business.industry T-cell receptor lcsh:R Histocompatibility Antigens Class II virus diseases Hepatitis C Chronic Middle Aged Receptors OX40 Hepatitis C digestive system diseases Chronic infection 030104 developmental biology Acute Disease Immunology biology.protein Female lcsh:Q business 030217 neurology & neurosurgery CD8 |
| Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | The combined regulation of a network of inhibitory and activating T cell receptors may be a critical step in the development of chronic HCV infection. Ex vivo HCV MHC class I + II tetramer staining and bead-enrichment was performed with baseline and longitudinal PBMC samples of a cohort of patients with acute, chronic and spontaneously resolved HCV infection to assess the expression pattern of the co-inhibitory molecule TIGIT together with PD-1, BTLA, Tim-3, as well as OX40 and CD226 (DNAM-1) of HCV-specific CD4+ T cells, and in a subset of patients of HCV-specific CD8+ T cells. As the main result, we found a higher expression level of TIGIT+ PD-1+ on HCV-specific CD4+ T cells during acute and chronic HCV infection compared to patients with spontaneously resolved HCV infection (p |
| Databáze: | OpenAIRE |
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