Norovirus infection and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil
| Autor: | Denise Cotrim da Cunha, Carina Pacheco Cantelli, Johan Nordgren, Patrícia Brasil, José Paulo Gagliardi Leite, Lennart Svensson, Marcia Terezinha Baroni de Moraes, Marize Pereira Miagostovich, Tulio Machado Fumian, Fábio Correia Malta |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Genotype viruses 030106 microbiology Population Biology medicine.disease_cause Microbiology Cohort Studies 03 medical and health sciences fluids and secretions Lewis Blood Group Antigens Rotavirus Genetics medicine Genetic predisposition Humans Genetic Predisposition to Disease education Molecular Biology Genotyping Ecology Evolution Behavior and Systematics Caliciviridae Infections education.field_of_study Genetic diversity Incidence (epidemiology) Incidence Norovirus Infant Newborn virus diseases Genetic Variation Infant Fucosyltransferases Virology digestive system diseases 030104 developmental biology Infectious Diseases Mutation Brazil |
| Zdroj: | Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 82 |
| ISSN: | 1567-7257 |
| Popis: | Norovirus has emerged as an important viral agent of acute pediatric gastroenteritis, with a growing genetic diversity reported in the last decades. Histo-blood group antigens (HBGAs) present on the surface of enterocytes are susceptibility factors for norovirus infection and differ between populations which could affects the epidemiology and evolution of these viruses. This study investigated the frequency, incidence and genetic diversity of noroviruses in a cohort of rotavirus A vaccinated children in association to the host HBGA (Secretor/Lewis) genetic susceptibility profile. Norovirus genogroups I and II (GI/GII) were screened by RT-qPCR in 569 stool samples from 132 children followed-up from birth to 11 months of age during 2014--2018. Noroviruses were identified in 21.2% of children enrolled in this study, with a norovirus detection rate of 5.6% (32/569), in 17.1% and 4.7% of acute diarrheic episodes (ADE) and non-ADE, respectively. The norovirus incidence was 5.8 infections per 100 child-months. Partial nucleotide sequencing characterized six different norovirus genotypes, with GII.4 Sydney 2012 being detected in 50% associated with three different polymerase genotypes (GII·P31, GII·P16 and GII·P4 New Orleans 2009). FUT3 genotyping was yielded seven new mutations in this population. A significant association between symptomatic norovirus infection and secretor profile could be inferred. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect