Comparative Study of the Effects of Free Bound and Carrier Protein Angiotensin II in Experimental Hypoglycemia and Hyperglycemia
| Autor: | B. B. Shoibonov, S. M. Tolpygo, A. V. Kotov, E. I. Pevtsova |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty endocrine system diseases Drinking Behavior Hemodynamics Blood Pressure S100 Calcium Binding Protein beta Subunit Hypoglycemia General Biochemistry Genetics and Molecular Biology Heart Rate Internal medicine medicine Animals Rats Wistar Acute hypoglycemia Bovine serum albumin Acute hyperglycemia biology Chemistry Angiotensin II nutritional and metabolic diseases Serum Albumin Bovine General Medicine medicine.disease Transport protein Endocrinology Carrier protein Hyperglycemia biology.protein Thirst |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 156:419-422 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Experimental hypoglycemia and hyperglycemia eliminated the differences in the regulatory functions of free angiotensin II and its complexes with carrier proteins (transport protein BSA and neurospecific protein S100b) in rats. Under these conditions, free and protein-bound angiotensin II primarily suppressed operant drinking behavior and reduced the hypertensive and tachyarrhythmic effects in comparison with control rats. These changes were most pronounced during acute hyperglycemia. We hypothesized that complexes of angiotensin II with functionally different proteins are differentially and simultaneously involved in not only compensation of behavioral and hemodynamic disturbances during acute and/or chronic hypoglycemia and hyperglycemia, but also their transformation into pathological processes mediated by the so-called metabolic memory mechanisms. |
| Databáze: | OpenAIRE |
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