Screening for Cushing’s Syndrome in Obese Patients
| Autor: | Demet Ozgil Yetkin, Ozay Tiryakioglu, Serdal Ugurlu, Serap Yalin, Erkan Caglar, Sibel Yirmibeşcik, Pinar Kadioglu |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Hydrocortisone Cushing's syndrome Gastroenterology Dexamethasone Cortisol Adrenocortical adenoma Cushing syndrome Reference Values Internal medicine medicine Humans Adrenocortical carcinoma Obesity Cushing Syndrome Glucocorticoids lcsh:R5-920 S syndrome business.industry General Medicine Clinical Science Adrenocorticorticotropic hormone medicine.disease Endocrinology Cushing’s syndrome Dexamethasone suppression test Screening Female lcsh:Medicine (General) business Biomarkers Brazil medicine.drug |
| Zdroj: | Clinics, Volume: 65, Issue: 1, Pages: 13-9, Published: 2010 Clinics, Vol 65, Iss 1, Pp 9-13 (2010) Clinics Clinics; v. 65 n. 1 (2010); 9-13 Clinics; Vol. 65 Núm. 1 (2010); 9-13 Clinics; Vol. 65 No. 1 (2010); 9-13 Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1807-5932 1980-5322 |
| Popis: | OBJECTIVES: The aim of this study was to examine the frequency of Cushing's syndrome (CS) in obese patients devoid of specific clinical symptoms of Cushing's syndrome. METHODS: A total of 150 obese patients (129 female, 21 male; mean age 44.41 ± 13.34 yr; mean BMI 35.76 ± 7.13) were included in the study. As a first screening step, we measured 24-h urinary free cortisol (UFC). An overnight 1-mg dexamethasone suppression test was also performed on all patients. Urinary free cortisol levels above 100 μg/24 h were considered to be abnormal. Suppression of serum cortisol 100 μg/24 h) were recorded in 37 patients (24%). Cushing's syndrome was diagnosed in 14 of the 150 patients (9.33%). Etiologic reasons for Cushing's syndrome were pituitary microadenoma (9 patients), adrenocortical adenoma (3 patients), and adrenocortical carcinoma (1 patient). CONCLUSION: A significant proportion (9.33%) of patients with simple obesity were found to have Cushing's syndrome. These findings argue that obese patients should be routinely screened for Cushing's syndrome. |
| Databáze: | OpenAIRE |
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