Broca's region subserves imagery of motion: A combined cytoarchitectonic and fMRI study
| Autor: | Klaus Martin Stephan, Stefan Posse, Karl Zilles, Katrin Amunts, Thorsten Schormann, Hans-Joachim Freund, Rüdiger J. Seitz, Ferdinand Binkofski |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Movement Posterior parietal cortex Intraparietal sulcus Fingers Premotor cortex Motion motor imagery Motor imagery cytoarchitectonics premotor cortex medicine Humans Radiology Nuclear Medicine and imaging ddc:610 Radiological and Ultrasound Technology medicine.diagnostic_test fMRI Motor Cortex Somatosensory Cortex Original Articles Magnetic Resonance Imaging Frontal Lobe Broca's region medicine.anatomical_structure parietal cortex nervous system Neurology Cytoarchitecture Cerebral hemisphere Imagination movement control Neurology (clinical) Anatomy Functional magnetic resonance imaging Psychology Neuroscience Psychomotor Performance |
| Zdroj: | Human brain mapping 11, 273-285 (2000). doi:10.1002/1097-0193(200012)11:4<273::AID-HBM40>3.0.CO;2-0 Hum Brain Mapp |
| ISSN: | 1097-0193 1065-9471 |
| DOI: | 10.1002/1097-0193(200012)11:4<273::aid-hbm40>3.0.co;2-0 |
| Popis: | Broca's region in the dominant cerebral hemisphere is known to mediate the production of language but also contributes to comprehension. Here, we report the differential participation of Broca's region in imagery of motion in humans. Healthy volunteers were studied with functional magnetic resonance imaging (fMRI) while they imagined movement trajectories following different instructions. Imagery of right-hand finger movements induced a cortical activation pattern including dorsal and ventral portions of the premotor cortex, frontal medial wall areas, and cortical areas lining the intraparietal sulcus in both cerebral hemispheres. Imagery of movement observation and of a moving target specifically activated the opercular portion of the inferior frontal cortex. A left-hemispheric dominance was found for egocentric movements and a right-hemispheric dominance for movement characteristics in space. To precisely localize these inferior frontal activations, the fMRI data were coregistered with cytoarchitectonic maps of Broca's areas 44 and 45 in a common reference space. It was found that the activation areas in the opercular portion of the inferior frontal cortex were localized to area 44 of Broca's region. These activations of area 44 can be interpreted to possibly demonstrate the location of the human analogue to the so-called mirror neurones found in inferior frontal cortex of nonhuman primates. We suggest that area 44 mediates higher-order forelimb movement control resembling the neuronal mechanisms subserving speech. Hum. Brain Mapping 11:273-285, 2000. (C) 2000 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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