Unlocking mammalian regeneration through hypoxia inducible factor one alpha signaling
| Autor: | Kelsey G. DeFrates, Phillip B. Messersmith, Ellen Heber-Katz, Daniela Franco |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Biophysics
Bioengineering 02 engineering and technology Regenerative medicine Article Biomaterials 03 medical and health sciences Mice Downregulation and upregulation Animals Progenitor cell Hypoxia Zebrafish Transcription factor 030304 developmental biology Mammals 0303 health sciences Wound Healing biology Regeneration (biology) 021001 nanoscience & nanotechnology biology.organism_classification Hypoxia-Inducible Factor 1 alpha Subunit Cell Hypoxia Murphy Roths Large Cell biology Hypoxia-inducible factors Mechanics of Materials Ceramics and Composites 0210 nano-technology Signal Transduction |
| Zdroj: | Biomaterials |
| ISSN: | 1878-5905 |
| Popis: | Historically, the field of regenerative medicine has aimed to heal damaged tissue through the use of biomaterials scaffolds or delivery of foreign progenitor cells. Despite 30 years of research, however, translation and commercialization of these techniques has been limited. To enable mammalian regeneration, a more practical approach may instead be to develop therapies that evoke endogenous processes reminiscent of those seen in innate regenerators. Recently, investigations into tadpole tail regrowth, zebrafish limb restoration, and the super- healing Murphy Roths Large (MRL) mouse strain, have identified ancient oxygen-sensing pathways as a possible target to achieve this goal. Specifically, upregulation of the transcription factor, hypoxia-inducible factor one alpha (HIF-1α) has been shown to modulate cell metabolism and plasticity, as well as inflammation and tissue remodeling, possibly priming injuries for regeneration. Since HIF-1α signaling is conserved across species, environmental or pharmacological manipulation of oxygen-dependent pathways may elicit a regenerative response in non-healing mammals. In this review, we will explore the emerging role of HIF-1α in mammalian healing and regeneration, as well as attempts to modulate protein stability through hyperbaric oxygen treatment, intermittent hypoxia therapy, and pharmacological targeting. We believe that these therapies could breathe new life into the field of regenerative medicine. |
| Databáze: | OpenAIRE |
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