Churg-Strauss Syndrome Concomitant with Chronic Symmetrical Dacryoadenitis Suggesting Mikulicz's Disease
| Autor: | Yusuke Hanioka, Masatsugu Kishida, Toshimasa Yamaguchi, Katsunobu Yoshioka, Tomoyuki Nakamura, Naomi Koshimo, Masahito Imanishi, Tomomi Nakamura, Takeshi Inoue, Keiko Yamagami |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology medicine.medical_specialty Prednisolone Plasma Cells Mucous membrane of nose Neurological examination Churg-Strauss Syndrome Methylprednisolone Mikulicz' Disease Antibodies Antineutrophil Cytoplasmic Dacryocystitis immune system diseases hemic and lymphatic diseases Internal Medicine medicine Humans cardiovascular diseases Aged medicine.diagnostic_test business.industry Lacrimal Apparatus Dacryoadenitis Immunoglobulins Intravenous General Medicine Immunoglobulin E Eosinophil medicine.disease respiratory tract diseases Treatment Outcome medicine.anatomical_structure Immunoglobulin G IgG4-related disease business medicine.drug |
| Zdroj: | Internal Medicine. 51:2457-2461 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.51.7725 |
| Popis: | A case of Churg-Strauss syndrome complicated by chronic symmetrical dacryoadenitis suggestive of Mikulicz's disease is herein presented. A 72-year-old Japanese man, who had been previously diagnosed with asthma, presented with weakness of the left leg and purpura on the lower extremities. A neurological examination showed multiple mononeuropathies and a laboratory examination revealed elevated eosinophil counts, IgE levels and the presence of Myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCAs). Churg-Strauss syndrome was diagnosed, although the patient also exhibited bilateral swelling of the lachrymal glands. Furthermore, elevated serum IgG4 levels, an infiltration of a relatively large number of IgG4-positive plasmacytes in the nasal mucosa and hypocomplementemia were also observed. These findings were consistent with a diagnosis of Mikulicz's disease (MD). Oral prednisolone (30 mg) was administered and the swelling of the lachrymal glands resolved. Churg-Strauss syndrome may be accompanied by Mikulicz's disease (an IgG4-related disease), and common pathogeneses between Churg-Strauss syndrome and IgG4-related disease may exist. |
| Databáze: | OpenAIRE |
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