Benzylation of hydroxy groups with tertiary amine as a base
| Autor: | Toshihide Maki, J.W. Gathirwa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
inorganic chemicals Tertiary amine Base (chemistry) Chemistry Solventless reaction organic chemicals Organic Chemistry Halide Alcohol C-O coupling Biochemistry Benzylation chemistry.chemical_compound Reaction temperature Benzyl ether Sodium iodide Drug Discovery Organic chemistry heterocyclic compounds Efficient catalyst |
| Zdroj: | Tetrahedron. 68(1):370-375 |
| ISSN: | 0040-4020 |
| Popis: | The benzylation of hydroxy groups in the presence of tertiary amines is described. A mixture of an alcohol and a benzyl halide afforded the corresponding benzyl ether in good to excellent yields in the presence of diisopropylethylamine. The importance of solventless conditions was observed. The reaction showed high tolerance to many functional groups including benzoate, even at a reaction temperature of 150 °C. Sodium iodide was found to be an efficient catalyst to accelerate the reaction. Tetrahedron, 68(1), pp.370-375; 2012 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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