Chronic recording and electrochemical performance of amorphous silicon carbide-coated Utah electrode arrays implanted in rat motor cortex
| Autor: | Alexandra Joshi-Imre, Sandeep Negi, Joseph J. Pancrazio, Loren Rieth, Rashed T. Rihani, Aswini Kanneganti, Justin Abbott, Jimin Maeng, Stuart F. Cogan, Vindhya Reddy Danda, Bryan J. Black, Bitan Chakraborty, Rohit Sharma |
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| Rok vydání: | 2019 |
| Předmět: |
Amorphous silicon
Materials science Carbon Compounds Inorganic 0206 medical engineering Biomedical Engineering 02 engineering and technology engineering.material Carbide 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Coating Coated Materials Biocompatible Electrode array Animals Rats Long-Evans Silicon Compounds Motor Cortex Extracellular Fluid Electrochemical Techniques 020601 biomedical engineering Dielectric spectroscopy Electrodes Implanted Rats Microelectrode chemistry Electrode engineering Cyclic voltammetry Microelectrodes 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | Journal of neural engineering. 16(4) |
| ISSN: | 1741-2552 |
| Popis: | Objective Clinical applications of implantable microelectrode arrays are currently limited by device failure due to, in part, mechanical and electrochemical failure modes. To overcome this challenge, there is significant research interest in the exploration of novel array architectures and encapsulation materials. Amorphous silicon carbide (a-SiC) is biocompatible and corrosion resistant, and has recently been employed as a coating on biomedical devices including planar microelectrode arrays. However, to date, the three-dimensional Utah electrode array (UEA) is the only array architecture which has been approved by the food and drug administration (FDA) for long-term human trials. Approach Here, we demonstrate, for the first time, that UEAs can be fabricated with a-SiC encapsulation and sputtered iridium oxide film (SIROF) electrode coatings, and that such arrays are capable of single-unit recordings over a 30 week implantation period in rat motor cortex. Over the same period, we carried out electrochemical measurements, including voltage transients, cyclic voltammetry, and electrochemical impedance spectroscopy (EIS), to evaluate potential failure modes. Furthermore, we evaluated chronic foreign body response via fluorescence immunohistochemistry following device explantation. Main results During the indwelling period, we observed a reduction in active electrode yield percentage from 94.6 ± 5.4 (week 1) to 16.4 ± 11.5% (week 30). While the average active electrode yield showed a steady reduction, it is noteworthy that 3 out of 8 UEAs recorded greater than 60% active electrode yield at all times through 24 weeks and 1 out of 8 UEAs recorded greater than 60% active electrode yield at all times through the whole implantation period. Significance In total, these findings further suggest that a-SiC may serve as a mechanically and electrochemically stable device encapsulation alternative to polymeric coatings such as Parylene-C. |
| Databáze: | OpenAIRE |
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