Muscle Cells Provide Instructions for Planarian Regeneration
| Autor: | Mirjam Mayer, Daniel E. Wagner, Jared H. Owen, Peter W. Reddien, Jessica N. Witchley |
|---|---|
| Přispěvatelé: | Massachusetts Institute of Technology. Department of Biology, Whitehead Institute for Biomedical Research, Owen, Jared Huntsman, Witchley, Jessica N., Mayer, Mirjam, Wagner, Daniel E., Reddien, Peter |
| Rok vydání: | 2013 |
| Předmět: |
Pluripotent Stem Cells
Cell type 1.1 Normal biological development and functioning Cellular differentiation Myoblasts Skeletal Medical Physiology Muscle Fibers Skeletal Regenerative Medicine Muscle Fibers General Biochemistry Genetics and Molecular Biology Article Myoblasts 03 medical and health sciences Myocyte Animals Regeneration Induced pluripotent stem cell lcsh:QH301-705.5 Gene Position control 030304 developmental biology 0303 health sciences biology 030302 biochemistry & molecular biology Cell Differentiation Skeletal Planarians Stem Cell Research biology.organism_classification Molecular biology 3. Good health Cell biology Wnt Proteins lcsh:Biology (General) Planarian Musculoskeletal Intercellular Signaling Peptides and Proteins Stem Cell Research - Nonembryonic - Non-Human Body region Biochemistry and Cell Biology |
| Zdroj: | Cell reports Elsevier Cell reports, vol 4, iss 4 Cell Reports, Vol 4, Iss 4, Pp 633-641 (2013) |
| ISSN: | 2211-1247 |
| DOI: | 10.1016/j.celrep.2013.07.022 |
| Popis: | Regeneration requires both potential and instructions for tissue replacement. In planarians, pluripotent stem cells have the potential to produce all new tissue. The identities of the cells that provide regeneration instructions are unknown. Here, we report that position control genes (PCGs) that control regeneration and tissue turnover are expressed in a subepidermal layer of nonneoblast cells. These subepidermal cells coexpress many PCGs. We propose that these subepidermal cells provide a system of body coordinates and positional information for regeneration, and identify them to be muscle cells of the planarian body wall. Almost all planarian muscle cells express PCGs, suggesting a dual function: contraction and control of patterning. PCG expression is dynamic in muscle cells after injury, even in the absence of neoblasts, suggesting that muscle is instructive for regeneration. We conclude that planarian regeneration involves two highly flexible systems: pluripotent neoblasts that can generate any new cell type and muscle cells that provide positional instructions for the regeneration of any body region. National Institutes of Health (U.S.) (NIH R01GM080639) W. M. Keck Foundation Helen Hay Whitney Foundation (postdoctoral fellowship) |
| Databáze: | OpenAIRE |
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