Association study of cell cycle proteins and human papillomavirus in laryngeal cancer in Chinese population

Autor:	Congling Qu, Honggang Liu, Lifang Cui
Rok vydání:	2019
Předmět:	Adult Male Oncology China medicine.medical_specialty Biopsy Cell Cell Cycle Proteins Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine Genotype Biomarkers Tumor medicine Humans 030223 otorhinolaryngology Basaloid Squamous Cell Carcinoma Laryngeal Neoplasms Aged Retrospective Studies Aged 80 and over Human papillomavirus 16 Tissue microarray business.industry Incidence Papillomavirus Infections virus diseases Cancer Middle Aged Cell cycle medicine.disease Immunohistochemistry medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis DNA Viral Carcinoma Squamous Cell Female business Follow-Up Studies
Zdroj:	Clinical Otolaryngology. 44:323-329
ISSN:	1749-4486 1749-4478
DOI:	10.1111/coa.13296
Popis:	Objective To investigate the role of human papillomavirus (HPV) in laryngeal squamous cell carcinoma (LSCC) and analyse the relationship between HPV and the expression of cell cycle-related proteins. Design The study consisted of LSCC between 2005 and 2011 in Tongren Hospital. Clinical data such as age, sex, smoking/alcohol consumption, and TNM stage were collected. HPV DNA and cell cycle-related proteins were assessed in terms of clinical features. Setting Single-centre study. Participants A total of 332 LSCC patients were included in the study. Main outcome measures The presence of genotype-specific HPV DNA was evaluated using PCR-RDB in formalin-fixed paraffin-embedded tissues. All samples were also evaluated for p16INK4A , p21WAF1/CIP1 , P53, Cyclin D1, and Ki67 immunohistochemical staining by tissue microarray. Results HPV DNA was detected in 45 of 332 (13.55%) patients with LSCC, with HPV-16 being the predominant genotype. The presence of HPV-16 DNA was significantly associated with basaloid squamous cell carcinoma and cystic lymph node metastasis (P 0.05). Conclusion HPV DNA was detected in 13.55% patients with LSCC, with HPV-16 being the predominant genotype and it was correlated with p16INK4A and manifested a higher Ki-67 labelling index and p21WAF1/CIP1 expression than HPV-16-negative tumours.
Databáze:	OpenAIRE
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