A systems biology view of blood vessel growth and remodelling
| Autor: | Elizabeth A. Logsdon, Aleksander S. Popel, Feilim Mac Gabhann, Stacey D. Finley |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Angiogenesis
Systems biology Physiology Neovascularization Physiologic Review Biology Models Biological Quantitative biology 03 medical and health sciences angiogenesis 0302 clinical medicine medicine Animals Humans Process (anatomy) multi-scale modelling 030304 developmental biology 0303 health sciences Systems Biology Cell Biology computational model medicine.anatomical_structure Pharmacological interventions Vascular network 030220 oncology & carcinogenesis Molecular Medicine Endothelium Vascular Neuroscience mathematical model Blood vessel |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-4934 |
| Popis: | Blood travels throughout the body in an extensive network of vessels – arteries, veins and capillaries. This vascular network is not static, but instead dynamically remodels in response to stimuli from cells in the nearby tissue. In particular, the smallest vessels – arterioles, venules and capillaries – can be extended, expanded or pruned, in response to exercise, ischaemic events, pharmacological interventions, or other physiological and pathophysiological events. In this review, we describe the multi-step morphogenic process of angiogenesis – the sprouting of new blood vessels – and the stability of vascular networks in vivo. In particular, we review the known interactions between endothelial cells and the various blood cells and plasma components they convey. We describe progress that has been made in applying computational modelling, quantitative biology and high-throughput experimentation to the angiogenesis process. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text