The prognostic value of QTC interval and QT dispersion following myocardial infarction in patients treated with or without dofetilide
| Autor: | Lars Køber, Bente Brendorp, Christian Torp-Pedersen, Hanne Elming, Li Jun |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Heart disease Systole Denmark Myocardial Infarction Clinical Investigations Dofetilide QT interval Electrocardiography Ventricular Dysfunction Left Double-Blind Method Risk Factors Internal medicine Phenethylamines medicine Humans cardiovascular diseases Myocardial infarction Risk factor Aged Proportional Hazards Models Aged 80 and over Sulfonamides medicine.diagnostic_test business.industry General Medicine Middle Aged Prognosis medicine.disease Survival Analysis Long QT Syndrome Treatment Outcome Anesthesia Multivariate Analysis Cardiology Myocardial infarction complications Female Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents Follow-Up Studies medicine.drug |
| Zdroj: | Clinical Cardiology. 26:219-225 |
| ISSN: | 1932-8737 0160-9289 |
| DOI: | 10.1002/clc.4960260505 |
| Popis: | Department of Cardiology, Copenhagen University Hospital, Gentofte; and *Department of Cardiology, Copenhagen UniversityHospital, Rigshospitalet, DenmarkSummaryBackground: Acute myocardial infarction (MI) is associat-ed with an increased risk of death, with a 1-year mortalityclose to 10% in patients discharged from hospital alive. Duringthe first year following MI, close to 50% of deaths are assumedto be due to arrhythmic events.Hypothesis: The study was undertaken to determine the in-teraction between dofetilide treatment and pretreatment QTcinterval and QT dispersion regarding mortality in patients withleft ventricular (LV) dysfunction and a recent MI.Methods: The study population consisted of 894 patientswith a recent MI and LV systolic dysfunction, who were ran-domized to receive dofetilide or placebo. The study was a sub-study of the Danish Investigations of Arrhythmia and Mortal-ity on Dofetilide-MI (DIAMOND-MI).Results: During a minimum of 1-year follow-up, 261(29%) patients died. Baseline QTc interval did not hold anyprognostic value on mortality for placebo-treated patients.When pretreatment QTc interval was 429 ms, dofetilide did not influ-ence mortality significantly. This study revealed no statisti-cally significant relation between QT dispersion, dofetilidetreatment, and mortality.Conclusion: In patients with a recent MI, LV dysfunction,and a short baseline QTc interval, dofetilide is associated withsignificant survival benefit. This benefit is not seen with alonger QTc interval. QT dispersion is not a risk factor in thispopulation.Key words: QT interval, QT dispersion, prognosis, antiar-rhythmic agents, myocardial infarctionIntroductionAcute myocardial infarction (MI) is associated with an in-creased risk of death, with a 1-year mortality close to 10% inpatients discharged from hospital alive. |
| Databáze: | OpenAIRE |
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