Hyperandrogenemia is Common in Asymptomatic Women and is Associated with Increased Metabolic Risk
| Autor: | Laura C. Torchen, Prathima Jasti, Matthew Dapas, Margrit Urbanek, Rodrigo Macaya, Andrea Dunaif, M. Geoffrey Hayes, Joy N. Tsai, Ryan Sisk |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Adolescent Cross-sectional study Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Physiology Asymptomatic Article chemistry.chemical_compound Young Adult Endocrinology Sex hormone-binding globulin Dehydroepiandrosterone sulfate medicine Humans Metabolic Syndrome Nutrition and Dietetics biology business.industry Hyperandrogenism Odds ratio medicine.disease Polycystic ovary Cross-Sectional Studies chemistry biology.protein Female medicine.symptom Metabolic syndrome business |
| Zdroj: | Obesity (Silver Spring) |
| ISSN: | 1930-739X |
| Popis: | OBJECTIVE Women with metabolic syndrome (MetS) have higher endogenous testosterone (T) levels than unaffected women. This study investigated whether hyperandrogenemia (HA) was a marker for increased cardiometabolic risk in reproductively normal premenopausal women. METHODS Reproductive hormones and metabolic parameters were assessed in 198 women with regular menses and no clinical hyperandrogenism (eumenorrheic [EM]). Hyperandrogenic EM women were compared with 110 women with NIH criteria polycystic ovary syndrome. RESULTS Twenty-two percent of EM women had HA. Levels of non-sex hormone-binding globulin (SHBG)-bound T were elevated in 68% of women, total T levels were elevated in 43% of women, and dehydroepiandrosterone sulfate levels were elevated in 30% of women. The prevalence of HA increased with BMI category (P = 0.01): 12% for BMI |
| Databáze: | OpenAIRE |
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