Studies to elucidate the mechanism of fenarimol-induced infertility in male rats
| Autor: | N.V. Owen, E. R. Adams, Kenneth Steven Hirsch, Janet K. Markham, D.G. Hoffman |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
Infertility medicine.medical_specialty Administration Oral Biology Toxicology chemistry.chemical_compound Pregnancy Internal medicine Placenta Lactation medicine Animals Fenarimol Carbon Radioisotopes Maternal-Fetal Exchange Infertility Male Pharmacology Rats Inbred Strains Organ Size Fetal Blood medicine.disease Sperm Rats Milk Pyrimidines Endocrinology medicine.anatomical_structure chemistry Hypothalamus Gestation Female |
| Zdroj: | Toxicology and Applied Pharmacology. 86:391-399 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(86)90366-2 |
| Popis: | Fenarimol (alpha-(2-chlorophenyl)-alpha-(4-chlorophenyl)-5- pyrimidinemethanol a pyrimidine carbinol fungicide, caused a dose-related decrease in male fertility in Wistar rats. The effect was particularly evident in the anatomically normal progeny of dams treated with fenarimol throughout gestation and lactation. Based on the observation that the infertility was associated with the absence of vaginal sperm at the time of mating, the effect appeared to be the result of an absence of male sexual behavior. Fenarimol does not readily cross the placenta but does concentrate in milk, reaching three- to fivefold higher concentrations than those observed in the maternal plasma. These results suggest that fenarimol might be acting to block the perinatal development of male patterns of sexual behavior which involves the action of gonadal steroids within the central nervous system (CNS). To test this hypothesis, [14C]fenarimol was administered to dams and the radioactivity measured in the brains of the neonates. Radioactivity in the hypothalamus was three- to fourfold higher and the half-life four times longer than that observed in the remainder of the brain. Since the hypothalamus is believed to play a key role in the development and expression of male sexual behavior, it appears likely that fenarimol is acting centrally to decrease male sexual behavior, thereby decreasing male fertility. |
| Databáze: | OpenAIRE |
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