Anandamide vehicles: a comparative study
| Autor: | María Teresa Dannert, Esperanza Herradón, Angela Alsasua, Visitación López-Miranda, María Isabel Martín |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Polyunsaturated Alkamides medicine.medical_treatment Polysorbates Aorta Thoracic Arachidonic Acids In Vitro Techniques Pharmacology Phenylephrine chemistry.chemical_compound medicine.artery medicine Animals Vasoconstrictor Agents Dimethyl Sulfoxide Rats Wistar Saline Aorta Ethanol Dose-Response Relationship Drug Chemistry Anandamide Rats Vasodilation Biochemistry Solvents Carbachol Endothelium Vascular Cannabinoid Vascular function Endocannabinoids |
| Zdroj: | European Journal of Pharmacology. 505:151-161 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2004.10.017 |
| Popis: | Among the studies that investigate the vasorelaxation induced by anandamide, one of the most frequent differences is the use of distinct solvents that could modify vascular function and explain the controversial results described. The aims of this study were: to evaluate the influence of different cannabinoid vehicles in vascular function of rat aorta, and to compare the vasorelaxation induced by anandamide dissolved in different vehicles. Vehicles were: ethanol (70%), Tween 80/ethanol (2:1 and 1:1), 1:1:18 (Tween 80/ethanol/saline) and dimethylsulphoxide (DMSO) 0.5%. All the vehicles tested, except DMSO 0.5%, modified the vascular and/or the endothelial function in rat aorta rings. Anandamide caused a time- and concentration-dependent vasorelaxation in all the experimental groups except in ethanol group, but the mechanisms involved in its vasorelaxation appear to be different depending on the vehicle used. The results obtained with vehicles containing Tween 80 suggest a non-endothelial component in the vasorelaxation caused by anandamide, while those obtained with DMSO at 0.5% suggest an endothelial component in this vasorelaxation. |
| Databáze: | OpenAIRE |
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