ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
| Autor: | Samer R. Eid, Timothy Jegla, Taryn J. Earley, Andrea M. Peier, Anne C. Hergarden, Alison J. Reeve, Stuart Bevan, David Andersson, Peter McIntyre, Gina M. Story, Ardem Patapoutian, Sun Wook Hwang, Johannes Mosbacher, Todd R. Hricik |
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| Jazyk: | angličtina |
| Předmět: |
Ankyrins
TRPV3 Molecular Sequence Data TRPV1 Nerve Tissue Proteins CHO Cells Biology General Biochemistry Genetics and Molecular Biology Rats Sprague-Dawley Mice chemistry.chemical_compound Transient receptor potential channel Transient Receptor Potential Channels Cricetinae TRPM8 medicine Animals Amino Acid Sequence Neurons Afferent TRPA1 Cation Channel Cells Cultured TRPC Cation Channels Biochemistry Genetics and Molecular Biology(all) Icilin Membrane Proteins Nociceptors Thermoreceptors Anatomy Protein Structure Tertiary Rats Cold Temperature chemistry Capsaicin Biophysics Cold sensitivity Female Calcium Channels medicine.symptom |
| Zdroj: | Cell. (6):819-829 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/S0092-8674(03)00158-2 |
| Popis: | Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The combined range of temperatures that activate these channels covers a majority of the relevant physiological spectrum sensed by most mammals, with a significant gap in the noxious cold range. Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8. ANKTM1 is a distant family member of TRP channels with very little amino acid similarity to TRPM8. It is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM8. Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol. |
| Databáze: | OpenAIRE |
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