Cyclic Peptides from Oldenlandia affinis DC. Molecular and Biological Properties
| Autor: | Lorents Gran, Lars Skjeldal, Knut Sletten |
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| Rok vydání: | 2008 |
| Předmět: |
Staphylococcus aureus
Erythrocytes Magnetic Resonance Spectroscopy Protein Conformation Hemophilus influenzae Molecular Sequence Data Bioengineering In Vitro Techniques Hemolysis Peptides Cyclic Biochemistry Oldenlandia Uterine Contraction Oxytocics Biological property Escherichia coli Animals Humans Amino Acid Sequence Molecular Biology Peptide sequence Oldenlandia affinis chemistry.chemical_classification Uterine activity Chromatography Human blood Hemolytic Agents Uterus General Chemistry General Medicine Haemophilus influenzae Cyclic peptide Anti-Bacterial Agents Rats chemistry Antibiotic effect Molecular Medicine Female |
| Zdroj: | Chemistry & Biodiversity. 5:2014-2022 |
| ISSN: | 1612-1880 1612-1872 |
| DOI: | 10.1002/cbdv.200890184 |
| Popis: | A new isolation procedure for Kalata polypeptides from the tropical plant Oldenlandia affinis DC is described. Fractions were screened by thin-layer chromatography, and Van Urk positive fractions were tested for oxytocic activity in estrogenized rat uteri. By using this procedure, we were able to isolate and characterize three macrocyclic polypeptides with uterine activity. Their amino acid sequence and biological effects have been analyzed, and their NMR spectra were compared with those of the earlier ones. All three peptides showed hemolytic activity on human blood, and were tested for antibiotic effect against E. coli, Staphylococccus aureus, and Hemophilus influenzae. |
| Databáze: | OpenAIRE |
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