Blood Cytokine Concentration in Rats during Antigenic Treatment after a Single Long-Term Stress Exposure
| Autor: | I. V. Alekseeva, E. V. Nikenina, M E Chukhnina, A. Yu. Kozlov, A. Yu. Abramova, S. S. Pertsov, V. V. Chekhlov |
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| Rok vydání: | 2020 |
| Předmět: |
Lipopolysaccharides
Male 0301 basic medicine medicine.medical_specialty Time Factors Lipopolysaccharide Period (gene) medicine.medical_treatment Interleukin-1beta Gene Expression General Biochemistry Genetics and Molecular Biology Proinflammatory cytokine Immobilization Interferon-gamma 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Antigen Internal medicine medicine Animals Rats Wistar Inflammation Interleukin-6 Tumor Necrosis Factor-alpha business.industry General Medicine Interleukin-10 Rats 030104 developmental biology Endocrinology Cytokine chemistry Long term stress Tumor necrosis factor alpha Interleukin-4 Restraint stress business Stress Psychological 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 168:713-717 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-020-04786-w |
| Popis: | We studied changes in the blood cytokine profile of rats 3 h, 1 day, and 8 days after acute stress on the model of 24-h immobilization followed by LPS administration (100 μg/kg intraperitoneally). The concentration of proinflammatory cytokines (particularly of IL-1β and TNFα) significantly decreased at the early stage after stress exposure and physiological saline injection, but increased in the follow-up period and practically did not differ or even surpassed the control level by the end of observations. Under these conditions, the blood content of anti-inflammatory cytokine IL-10 increased most significantly on day 1 of the post-stress period. Restraint stress followed by LPS administration was accompanied by a decrease in the level of proinflammatory cytokines at the early (IFNγ and TNFα) and late stages (IL-1β) of the experiment. Directed modulation of the immune status in animals after acute stress was followed by a significant increase in the content of IL-10 on days 1 and 8, as well as by a tendency toward elevation of IL-4 concentration by the end of the study. The directionality and degree of changes in the cytokine profile of mammalian tissues depend on the type of extreme exposure, duration of the post-stress period, and specific effects of exogenous pathogenic factors in the whole body. |
| Databáze: | OpenAIRE |
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