Interleukin 6–174 G/C promoter and variable number of tandem repeats (VNTR) gene polymorphisms in sporadic Alzheimer's disease
| Autor: | Cristiano Capurso, Maria Lorusso, Vincenzo Solfrizzi, Davide Seripa, Francesco Panza, Marta Denitto, Bruno P. Imbimbo, Antonio Capurso, Alessia D'Introno, Gianluigi Vendemiale, Andrea Santamato, Vincenza Frisardi, Anna M. Colacicco, Alberto Pilotto, Pietro Fiore |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Apolipoprotein E Genotype Single-nucleotide polymorphism Locus (genetics) Minisatellite Repeats Biology Linkage Disequilibrium Apolipoproteins E Gene Frequency Alzheimer Disease Humans Genetic Predisposition to Disease Age of Onset Allele Promoter Regions Genetic Biological Psychiatry Aged Aged 80 and over Pharmacology Genetics Chi-Square Distribution Polymorphism Genetic Interleukin-6 Haplotype Middle Aged Genotype frequency Variable number tandem repeat Italy Case-Control Studies Female |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 34:177-182 |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/j.pnpbp.2009.10.022 |
| Popis: | Previous studies examining the association between the interleukin 6 (IL-6)-174 C/G polymorphism and Alzheimer's disease (AD) have yielded conflicting results. Furthermore, the C allele of the IL-6 variable number of tandem repeats (VNTR) polymorphism was associated with a delayed onset and a decreased risk of AD.A total sample of 149 AD patients, and 298 age- and sex-matched unrelated caregivers from Apulia, southern Italy, were genotyped for the apolipoprotein E (APOE) polymorphism, the VNTR polymorphism in the 3' flanking region, and the -174G/C single-nucleotide polymorphism (SNP) in the promoter region of IL-6 gene on chromosome 7. Furthermore, we performed a haplotype analysis on these two polymorphisms on IL-6 locus.IL-6 VNTR and -174G/C allele and genotype frequencies were similar between AD patients and controls, also after stratification for late-onset (or =65 years) and early-onset (65 years) or APOE epsilon4 status. Furthermore, there was no evidence of linkage disequilibrium between the VNTR and -174G/C polymorphisms, not supporting a previous reported additive effect of both IL-6 polymorphisms on AD risk.Our findings did not support a role of IL-6-174 G/C and IL-6 VNTR polymorphisms in the risk of sporadic AD in southern Italy, suggesting that these polymorphisms of IL-6 gene were at most weak genetic determinants of AD. |
| Databáze: | OpenAIRE |
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