Differential effects of nonselective versus selective β-blockers on cardiac sympathetic activity and hemostasis in patients with heart failure
| Autor: | Rienk Nieuwland, Wouter E.M. Kok, Hein J. Verberne, Ad Bakx, Pieter Willem Kamphuisen, Olav R. de Peuter, G. Aernout Somsen, Marianna C. Schaap, Bas van den Bogaard, Joost C. M. Meijers |
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| Přispěvatelé: | Cardiovascular Centre (CVC), Vascular Ageing Programme (VAP), Other departments, Amsterdam Cardiovascular Sciences, Nuclear Medicine, Cardiology, Intensive Care Medicine, Laboratory for Experimental Clinical Chemistry, Cancer Center Amsterdam, Vascular Medicine, Experimental Vascular Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Sympathetic nervous system heart failure BETA(2)-ADRENERGIC RECEPTOR Propanolamines genetics Carvedilol Metoprolol RISK Ejection fraction genetics coagulation Heart Middle Aged STATE 3-Iodobenzylguanidine medicine.anatomical_structure Treatment Outcome ADRENERGIC-RECEPTOR BLOCKADE Anesthesia Cardiology Female medicine.drug Acute coronary syndrome medicine.medical_specialty Adrenergic beta-Antagonists Carbazoles ACUTE-CORONARY-SYNDROME EVENTS beta-blockers Internal medicine medicine Humans Radiology Nuclear Medicine and imaging coagulation Radionuclide Imaging POLYMORPHISMS METAANALYSIS Aged sympathetic nervous system Hemostasis CARVEDILOL HYPERTENSION business.industry Patient Selection medicine.disease Crossover study Haplotypes Heart failure Receptors Adrenergic beta-2 business |
| Zdroj: | Journal of Nuclear Medicine, 54(10), 1733-1739. SOC NUCLEAR MEDICINE INC Journal of nuclear medicine, 54(10), 1733-1739. Society of Nuclear Medicine Inc. |
| ISSN: | 0161-5505 |
| Popis: | Carvedilol, a nonselective β-blocker, may be more effective than the selective β-blocker metoprolol in reducing the risk of thromboembolic events in heart failure. The aim of this study was, first, to assess whether there is a differential response in cardiac sympathetic activity by123I-meta-iodobenzylguanidine (123I-MIBG) imaging when either β-blocker is used. Second, we assessed whether that response correlates with levels of various serum factors that serve as markers for coagulability. Methods: In this prospective, randomized, open-label crossover study with masked outcome assessments, stable heart failure patients (left ventricular ejection fraction |
| Databáze: | OpenAIRE |
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