Polymorphisms of the ApoE (Apolipoprotein E) Gene and Their Influence on Dyslipidemia in HIV-1-Infected Individuals
| Autor: | Pornpen Srisawasdi, Chonlaphat Sukasem, Siwalee Santon, Tanida Suwalak, Napatrupron Koomdee, Angkana Charoenyingwattana, Montri Chamnanphon, Apichaya Puangpetch, Wasun Chantratita |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Microbiology (medical) Apolipoprotein E medicine.medical_specialty Adolescent Genotype Apolipoprotein B HIV Infections Young Adult Apolipoproteins E Internal medicine medicine Humans Aged Dyslipidemias Retrospective Studies Polymorphism Genetic biology medicine.diagnostic_test business.industry General Medicine Middle Aged Thailand medicine.disease Genotype frequency Infectious Diseases Endocrinology Anti-Retroviral Agents Case-Control Studies HIV-1 biology.protein Female lipids (amino acids peptides and proteins) Lipodystrophy business Lipid profile Dyslipidemia Lipoprotein |
| Zdroj: | Japanese Journal of Infectious Diseases. 68:5-12 |
| ISSN: | 1884-2836 1344-6304 |
| DOI: | 10.7883/yoken.jjid.2013.190 |
| Popis: | The purpose of this retrospective case-control study was to investigate the frequency of Apolipoprotein E (ApoE) polymorphisms and their influence on antiretroviral therapy (ART)-induced lipodystrophy or dyslipidemia in HIV-infected Thai patients. The clinical characteristics and frequencies of ApoE genotypes were compared between the case (moderate to severe lipodystrophy, n = 67) and control (absent to mild lipodystrophy, n = 18) groups. The ApoE genotype frequencies among the 85 participants were 2.35% (n = 2) for E2/E2, 20% (n = 17) for E2/E3, 9.41% (n = 8) for E2/E4, 36.47% (n = 31) for E3/E3, 30.59% (n = 26) for E3/E4, and 1.18% (n = 1) for E4/E4. None of the ApoE genotypes showed association with ART-induced lipodystrophy. However, the levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-cholesterol), and ApoB were lower in patients carrying the E2 allele but higher in E4 carriers. Interestingly, the ratios between TC and high-density lipoprotein (TC/HDL cholesterol ratio) and ApoB/ApoA-I ratio were significantly higher in the case group. Patients carrying the E2 allele displayed protective lipid profile, while those carrying E4 appeared to be at higher risk of dyslipidemia. In conclusion, ApoE polymorphisms were not associated with lipodystrophy in patients undergoing antiretroviral therapy but influenced lipid alteration. |
| Databáze: | OpenAIRE |
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