351 Prevalence of Thyroid Peroxidase Autoantibodies (ANTI-TPO) in Women with Autoimmune Connective Tissue Diseases (ACTD)
| Autor: | Ekarerini Anastasiou, Asimoula Koteli, Georgios Papadopoulos, Anastasia Vakaloudi, Eirene Koutsika |
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| Rok vydání: | 2012 |
| Předmět: |
Pulmonary and Respiratory Medicine
endocrine system Pathology medicine.medical_specialty endocrine system diseases Immunology Population Connective tissue Poster Session Autoimmune thyroiditis Thyroid peroxidase medicine Immunology and Allergy Positive test education education.field_of_study biology business.industry Autoantibody medicine.disease Abstracts of the XXII World Allergy Congress Anti-thyroid autoantibodies medicine.anatomical_structure biology.protein Antibody business |
| Zdroj: | The World Allergy Organization Journal |
| ISSN: | 1939-4551 |
| Popis: | Background Chronic autoimmune thyroiditis, manifested by positive test for antithyroid antibodies, is common in the general population, occurring in 10 to 20 percent of women. The aim of the study was to determine whether Anti-TPO is more prevalent in women with ACTD, compared to the general population. Methods Anti-TPO was determined in 290 women diagnosed with ACTD based on ACR (American College of Rheumatology) criteria and in 50 healthy women (control group). Among ACTD patients, 121 were diagnosed with Rheumatoid Arthritis (RA), 44 Systemic Lupus Erythematosus (SLE), 43 Sjοgren's Syndrome (SS), 42 Systemic Scleroderma (SScl) and 40 Psoriatic Arthritis (PsA). Anti-TPO was measured by Chemiluminescent Microparticle Immunoassay (CMIA) on Architect i2000SR (ABBOT Laboratories). Results The prevalence of Anti-TPO in separate groups of patients had as follow: RA 28.93%, SLE 29.55%, SS 27.91%, SScl 23.81%, PsA 30% and control group 12%. Conclusions ACTD and thyroid autoimmune diseases often overlap with each other. Increased Anti-TPO may be most common among women patients with ACTD. On the other hand, these systemic diseases are often present in Hasimoto's thyroiditis subjects. Therefore it is clinically important to screen women patients with ACTD for the co-existence of thyroid disorders. |
| Databáze: | OpenAIRE |
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