Rapid quantification of dimethyl methylphosphonate from activated carbon particles by static headspace gas chromatography mass spectrometry
| Autor: | Brit G. Billingsley, Brendan L. Mitchell, Brian A. Logue |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Analytical chemistry
chemistry.chemical_element Mass spectrometry Biochemistry Gas Chromatography-Mass Spectrometry Analytical Chemistry chemistry.chemical_compound Organophosphorus Compounds Adsorption Drug Stability Limit of Detection medicine Least-Squares Analysis Respiratory Protective Devices Detection limit Chromatography Dimethyl methylphosphonate Organic Chemistry Reproducibility of Results General Medicine chemistry Charcoal Gas chromatography Gas chromatography–mass spectrometry Carbon Activated carbon medicine.drug |
| Zdroj: | Journal of Chromatography A. 1293:120-125 |
| ISSN: | 0021-9673 |
| DOI: | 10.1016/j.chroma.2013.03.038 |
| Popis: | Activated carbon (AC) particles are utilized as an adsorbent for binding hazardous vapors in protective equipment. The binding affinity and utilization of these AC particles should be known to ensure effective and efficient use. Therefore, a simple and effective method was developed for the quantification of the chemical warfare agent simulant, dimethyl methylphosphonate (DMMP), from AC particles. Static headspace gas chromatography mass-spectrometry with internal standard, DMMP-d6, was used to perform the analysis. The method produced a linear dynamic range of 2.48-620g DMMP/kg carbon and a detection limit of 1.24g DMMP/kg carbon. Furthermore, the method produced a coefficient of variation of less than 16% for all intra- and inter-assay analyses. The method provided a simple and effective procedure for quantifying DMMP from AC particles and was applied to the analysis of a DMMP-exposed AC protective respirator filter. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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