Cardioprotective effect of Sida rhomboidea. Roxb extract against isoproterenol induced myocardial necrosis in rats
| Autor: | Ansarullah, Sanjay S. Karn, Menaka C. Thounaojam, Ravirajsinh N. Jadeja, A. V. Ramachandran, Jigar D. Shah, Dipak K. Patel, Ranjitsinh V. Devkar, Sunita P. Salunke, Geeta Padate |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Cardiotonic Agents Necrosis ATPase Endogeny Toxicology Pathology and Forensic Medicine Lipid peroxidation chemistry.chemical_compound Internal medicine Isoprenaline medicine Animals Myocardial infarction Malvaceae chemistry.chemical_classification biology Plant Extracts Myocardium Isoproterenol Heart Cell Biology General Medicine medicine.disease Lipids Rats Plant Leaves Enzyme Endocrinology chemistry Circulatory system biology.protein Lipid Peroxidation medicine.symptom Phytotherapy medicine.drug |
| Zdroj: | Experimental and Toxicologic Pathology. 63:351-356 |
| ISSN: | 0940-2993 |
| Popis: | The present study investigates cardioprotective effect of Sida rhomboidea. Roxb (SR) extract on heart weight, plasma lipid profile, plasma marker enzymes, lipid peroxidation, endogenous enzymatic and non-enzymatic antioxidants and membrane bound ATPases against isoproterenol (IP) induced myocardial necrosis (MN) in rats. Rats treated with IP (85 mg/kg, s.c.) recorded significant (p0.05) increment in heart weight, plasma lipid profile, plasma marker enzymes of cardiac damage, cardiac lipid peroxidation (LPO) and activity levels of Ca(+2) ATPase whereas there was significant (p0.05) decrease in plasma HDL, cardiac endogenous enzymatic and non-enzymatic antioxidants, Na(+)-K(+) ATPase and Mg(+2) ATPase. Pre-treatment with SR extract (400 mg/kg per day, p.o.) for 30 consecutive days followed by IP injections on days 29th and 30th, showed significant (p0.05) decrease in heart weight, plasma lipid profile, plasma marker enzymes of cardiac damage, cardiac lipid peroxidation, Ca(+2) ATPase and significant increase in plasma HDL, cardiac endogenous enzymatic and non-enzymatic antioxidants, Na(+)-K(+) ATPase and Mg(+2) ATPase compared to IP treated group. Hence, this study is the first scientific report on cardioprotective effect of SR against IP induced MN in rats. |
| Databáze: | OpenAIRE |
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