No evidence of intracellular oxidative stress during ischemia-reperfusion damage in rat liver in vivo
| Autor: | Pia Villa, Amalia Guaitani, Carmen Carugo |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant medicine.medical_treatment Ischemia Toxicology medicine.disease_cause chemistry.chemical_compound In vivo Internal medicine medicine Animals Aspartate Aminotransferases Amitrole chemistry.chemical_classification Reactive oxygen species Chemistry Alanine Transaminase General Medicine Glutathione medicine.disease Catalase Rats Endocrinology Liver Nitrofurantoin Reperfusion Injury Glutathione disulfide Oxidation-Reduction Oxidative stress Intracellular |
| Zdroj: | Toxicology letters. 61(2-3) |
| ISSN: | 0378-4274 |
| Popis: | The role of the intracellular generation of reactive oxygen species in the pathogenesis of ischemia reperfusion damage of the liver was investigated in two in vivo rat models. Global hepatic ischemia was produced in the left and median lobes for 90 min followed by 60 min reperfusion to the total organ (model A) or only to the ischemie lobes (model B). Although both regimens caused significant rises in serum transaminases, this rise was higher in model B. In neither model was intracellular hydrogen peroxide production nor increased glutathione disulfide in bile found. The activities of various antioxidant enzymes were not affected by ischemia or ischemia-reperfusion. In conclusion, oxygen-free radicals are unlikely to be produced in the cells of rat liver during ischemia-reperfusion. |
| Databáze: | OpenAIRE |
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