Altered sirtuin expression is associated with node-positive breast cancer
| Autor: | Alan MacIntyre, S. Zino, David B. Kingsmore, W.D. George, N. Ashraf, Anthony P. Payne, Paul G. Shiels |
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| Rok vydání: | 2006 |
| Předmět: |
Cyclin-Dependent Kinase Inhibitor p21
Cancer Research SIRT3 SIRT7 Breast Neoplasms Cell Line Mitochondrial Proteins breast cancer sirtuins Breast cancer Cell Line Tumor Sirtuin 3 Gene expression medicine Humans RNA Neoplasm Molecular Diagnostics Cellular Senescence Cyclin-Dependent Kinase Inhibitor p16 Analysis of Variance biology Carcinoma Ductal Breast Cancer Prognosis medicine.disease Gene Expression Regulation Neoplastic Oncology Ageing Lymphatic Metastasis Sirtuin gene expression biology.protein Cancer research Cell aging |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6603384 |
| Popis: | Sirtuins are genes implicated in cellular and organismal ageing. Consequently, they are speculated to be involved in diseases of ageing including cancer. Various cancers with widely differing prognosis have been shown to have differing and characteristic expression of these genes; however, the relationship between sirtuin expression and cancer progression is unclear. In order to correlate cancer progression and sirtuin expression, we have assessed sirtuin expression as a function of primary cell ageing and compared sirtuin expression in normal, ‘nonmalignant' breast biopsies to breast cancer biopsies using real-time polymerase chain reaction (PCR). Levels of SIRT7 expression were significantly increased in breast cancer (P |
| Databáze: | OpenAIRE |
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