‘Reductive Heck reaction’ of 6-halopurines

Autor:	Dalimil Dvorak, Tomáš Tobrman
Rok vydání:	2004
Předmět:	chemistry.chemical_classification Double bond Alkene Organic Chemistry Substituent Regioselectivity General Medicine Biochemistry Medicinal chemistry chemistry.chemical_compound chemistry Triethylammonium formate Heck reaction Drug Discovery Purine derivative Organic chemistry
Zdroj:	Tetrahedron Letters. 45:273-276
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2003.10.181
Popis:	Alkenylation of 9-benzyl-6-halopurines with alkenes does not proceed under conventional Heck conditions. However, in the presence of triethylammonium formate a mixture of the corresponding saturated products was obtained. In contrast to the classical Heck reaction, the regioselectivity of this process is low giving a mixture of both α- and β-products regardless of the electronic nature of the substituent on the double bond of the alkene.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dddc57546a277552706ce933d513a732 https://doi.org/10.1016/j.tetlet.2003.10.181 Zobrazit plný text záznamu Full Text from ScienceDirect